Ajuben is prescribed for:
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Ajuben (deutetrabenazine) acts as a reversible inhibitor of vesicular monoamine transporter 2 (VMAT2).
It reduces the uptake and storage of neurotransmitters like dopamine, serotonin, norepinephrine, and histamine in nerve terminals.
This depletion of monoamines helps control abnormal involuntary movements (chorea and dyskinesia).
Pediatrics: Not established in patients under 18
Hepatic/Renal Impairment: No specific studies available; use caution
Poor CYP2D6 Metabolizers: Limit dose to 36 mg/day (18 mg twice daily)
| Condition | Initial Dose | Maintenance Range | Max Dose |
|---|---|---|---|
| Chorea (Huntington’s) | 6 mg/day | 6–48 mg/day | 48 mg/day |
| Tardive Dyskinesia | 12 mg/day | 12–48 mg/day | 48 mg/day |
Titrate by 6 mg/day weekly
Divide doses ≥12 mg (e.g., 24 mg = 12 mg twice daily)
Take with food
| Tetrabenazine Dose | Initial Ajuben Dose |
|---|---|
| 12.5 mg | 6 mg once daily |
| 25 mg | 6 mg once daily |
| 37.5 mg | 9 mg once daily |
| 50 mg | 12 mg once daily |
| 62.5 mg | 15 mg once daily |
| 75 mg | 18 mg once daily |
| 87.5 mg | 21 mg once daily |
| 100 mg | 24 mg once daily |
Adjust Ajuben weekly as needed for clinical response.
Avoid strong CYP2D6 inhibitors (e.g., fluoxetine, paroxetine): Maximum dose = 36 mg/day
Avoid alcohol and sedatives: May cause additive drowsiness
Pregnancy: Not enough human data – use only if clearly needed
Breastfeeding: Unknown if secreted in milk – caution advised
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